Which metabolic pathway is the primary route of Paracetamol (Acetaminophen) metabolism in neonates, which helps compensate for the immaturity of the glucuronidation pathway? - Answer & Explanation
- Oxidation
- Sulfation ✓ Correct Answer
- Acetylation
- Hydrolysis
Explanation:
Paracetamol clearance is lower in neonates than in children and adults. After metabolic conversion, paracetamol is subsequently eliminated by the renal route. The main metabolic conversions are conjugation with glucuronic acid and with sulphate. In the urine of neonates sulphated paracetamol concentration is higher than the glucuronidated paracetamol level, suggesting that sulfation prevails over glucuronidation in neonates
Reference
Pacifici GM, Allegaert K. Clinical pharmacology of paracetamol in neonates: a review. Curr Ther Res Clin Exp. 2014 Dec 12;77:24-30. doi: 10.1016/j.curtheres.2014.12.001. PMID: 25709719; PMCID: PMC4329422